The Boston Marriott Long Wharf in Boston, Massachusetts is adjacent to the New England Aquarium, Faneuil Hall Marketplace, the Financial District and the historic Italian neighborhood of North End are one block away. Boston Logan International Airport is within five miles of the hotel. The waterfront New England Aquarium is located next to the hotel. The 200,000-gallon cylindrical Giant Ocean Tank is in the atrium of the main building. The tank simulates a Caribbean coral reef with sharks, turtles and smaller reef-living fish.

The hotel was designed to look like the inside of a luxury cruise ship, with a spacious lobby and use of bright red metal railings. It shares a wharf with Boston Harbor Cruises, which offers trips to harbor islands, lighthouses, and forts. This is one of the few hotels in Boston with easy access to the airport via water shuttle and underground public transportation. For guests arriving by car, the concierge has up-to-the-minute information on road conditions to help maneuver through detours around Boston's Big Dig construction.