Located one mile from the Las Vegas Strip, the Palms Casino Resort provides complimentary scheduled shuttle service to and from the Strip, with stops at the Forum Shops at Caesars Palace and Fashion Show Mall. In addition to a 90,000-square-foot casino, guests enjoy a two-acre, multi-level pool complex and a health spa with treatment rooms, fitness center, steam rooms, saunas, spa tubs, and a studio for Pilates and yoga classes.

The three-story Rain nightclub features an elevated dance floor, pyrotechnics, and VIP booths. Located on the 55th floor, Ghostbar has floor-to-ceiling windows and a Plexiglas dance floor on the balcony. The Pearl is an intimate concert venue. The Lounge offers live entertainment and special events. Restaurants include Alizé,which offers fine French cuisine and panoramic views, Garduńo's serves Mexican fare, N9NE Steak House is an offshoot of the popular Chicago restaurant, and Little Buddha is an Asian restaurant and sushi bar. NOVE Italiano offers redefined Italian cuisine. Other dining options include a buffet restaurant, a 24-hour café, a food court, and 24-hour room service.